论文部分内容阅读
从前列腺癌、前列腺炎、良性前列腺增生和未确诊的前列腺病变患者中行直肠按摩所得的前列腺液测定各种免疫蛋白试图找出前列隙癌患者所特有的标志。检查了免疫球蛋白IgG,IgA,IgM,补体C_3及C_4和转铁蛋白,前列豫液标本先作免疫电泳。发现前列腺癌与其他组患者之间补津C_3,C_4和转铁蛋白浓度有明显的不同。前列腺癌患者前列腺液在电泳凝胶中这些蛋白着色深而所有其他组的则不着色或着色浅。这些定性测定随后用放射免疫扩散技术作定量测定来取代。后者所得的结果证实了上述的观察,并指出前列腺癌患者比其他组患者的前列腺液中补体C_3、C_4和转铁蛋白的水平明显升高。这些资料说明前列腺液中测定补体C_3、C_4和转铁蛋白有助于对危害性大的前列腺癌患者作出诊断。
The prostatic fluid obtained by rectal massage from patients with prostate cancer, prostatitis, benign prostatic hyperplasia, and undiagnosed prostate lesions measures various immune proteins in an effort to find out the unique markers of patients with anterior gap cancer. Immunoglobulin IgG, IgA, IgM, complements C3 and C4, and transferrin were examined. Immunochemistry was performed on the samples of the forefront. It was found that the levels of C3, C4, and transferrin in prostate cancer were significantly different from those in other groups. Prostate fluids in prostatic cancer patients stained deep in the electrophoretic gel while all other groups were not colored or light. These qualitative assays were subsequently replaced by quantitative radioimmunoassay techniques. The results obtained by the latter confirm the above observations and indicate that prostate cancer patients have significantly higher levels of complement C3, C4, and transferrin in the prostatic fluid than other patients. These data suggest that the determination of complements C_3, C_4, and transferrin in prostatic fluid may help in the diagnosis of patients with high-risk prostate cancer.