3'-烷基-α-三联噻吩的合成及其杀线虫活性

• 作 者: 卜伟 张宇轩 杜超 程晓红
• 机 构: 云南大学化学科学与工程学院,
• 出 处: 农药学学报
• 发表日期: 2012年03期
• 关键词: 偶联反应 三联噻吩 烷基 化合物 杀伤率 合成 目标化合物 合成化合物 杀线虫活性 光照

以3-溴噻吩为原料,以Kumada偶联反应和Suzuki偶联反应为关键步骤合成了9个3’-烷基-α-三联噻吩类化合物8～16,其中5个为新化合物,其结构经1H NMR、MS和元素分析的表征和确证。采用光照法首次测定了9个合成化合物对全齿复活线虫Panagrellus redivivus的杀伤率。结果表明:除化合物13外,其余目标化合物在50μg/mL、照度为2 000 lx、光照时间为72 h条件下对全齿复活线虫的杀伤率均在85%以上。

Using 3-bromothiophene as the starting material, 9 3’-alkyl-α-tris-thiophenes 8-16 were synthesized with Kumada coupling reaction and Suzuki coupling reaction as the key steps. Five of them were new compounds, Characterization and confirmation by 1H NMR, MS and elemental analysis. The killing rate of 9 synthetic compounds to Panagrellus redivivus was determined by light illumination for the first time. The results showed that except for compound 13, the killing rates of all the other target compounds against all-toothed living nematodes were above 85% at 50 μg / mL, illumination of 2000 lx and illumination time of 72 h.