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目的:研究卡维地洛、硝苯地平及福辛普利在高血压伴焦虑患者中的降血压与抗焦虑疗效。方法:经导入期安慰剂治疗后舒张压95～115 mmHg及收缩压<180mmHg,贝克焦虑量表(BAI)评分>45分的32例患者为研究对象,采用自身交叉对照的方法,每例在不同治疗期分别给予卡维地洛、硝苯地平控释片及福辛普利治疗4周。观察血压及BAI评分的变化。结果:卡维地洛对收缩压和舒张压的降压作用比其他两组为佳,差异非常显著(P<0.01);BAI评分也显著下降(P<0.01)。结论:对于轻、中度高血压伴焦虑患者,卡维地洛的降血压和减轻焦虑效果较硝苯地平控释剂和福辛普利更好。
OBJECTIVE: To study the antihypertensive and anxiolytic effects of carvedilol, nifedipine and fosinopril in hypertensive patients with anxiety. Methods: Thirty-two patients with 95 ~ 115 mmHg diastolic blood pressure and systolic blood pressure <180 mmHg and BAI score> 45 after the induction period were enrolled in this study. Different treatment period were given carvedilol, nifedipine controlled release tablets and fosinopril treatment for 4 weeks. Blood pressure and BAI score changes were observed. Results: The antihypertensive effects of carvedilol on systolic and diastolic blood pressure were better than those in the other two groups (P <0.01). The BAI score also decreased significantly (P <0.01). CONCLUSIONS: Carvedilol has better antihypertensive and anti-anxiety effects than nifedipine and fosinopril in patients with mild to moderate hypertension and anxiety.