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目的:观察FOLFOX4方案一线治疗晚期胃癌的疗效及不良反应。方法:采用草酸铂、亚叶酸钙及5-氟尿嘧啶组成的FOLFOX4方案治疗晚期胃癌患者46例,14 d为1周期,2周期后评价疗效。结果:总有效率为47.8%,中位生存时间10.1个月。主要不良反应:周围性感觉神经病变、骨髓抑制及消化道反应,多数为Ⅰ~Ⅱ度。结论:FOLFOX4方案是一线治疗晚期胃癌的有效方案。
Objective: To observe the efficacy and side effects of FOLFOX4 regimen in the treatment of advanced gastric cancer. Methods: FOLFOX4 regimen consisting of oxaliplatin, leucovorin and 5-fluorouracil was used to treat 46 patients with advanced gastric cancer, 14 days for 1 cycle and 2 cycles for evaluation. Results: The total effective rate was 47.8% and the median survival time was 10.1 months. The main adverse reactions: peripheral sensory neuropathy, myelosuppression and gastrointestinal reactions, most of Ⅰ ~ Ⅱ degrees. Conclusion: The FOLFOX4 regimen is an effective first-line therapy for advanced gastric cancer.