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目的探讨肾上腺海绵状淋巴管瘤的病理学特征。方法收集3例肾上腺海绵状淋巴管瘤的临床病理资料并随访,所有标本均经HE染色、光镜观察和免疫组化染色。结果 3例均为男性,年龄30～75岁,平均51岁。光镜下瘤组织由大小不等的腔隙组成,腔内壁衬以单层扁平内皮细胞,腔内含有少数淋巴细胞,可见红细胞,腔隙之间的间质由胶原纤维组成,并见灶性淋巴细胞聚集。免疫组化:瘤细胞D2-40部分(+),CD31、CD34、EMA、SMA、CK5/6和calretinin均为(-)。结论肾上腺海绵状淋巴管瘤属淋巴系统的良性肿瘤,其特征性的组织形态、免疫组化表型有助于诊断和鉴别诊断。
Objective To investigate the pathological features of adrenal cavernous neoplasms. Methods The clinical data of 3 cases of adrenal cavernous lymphangioma were collected and followed up. All specimens were stained with HE, light microscopy and immunohistochemistry. Results 3 cases were male, aged 30 to 75 years, mean 51 years. Under the light microscope, the tumor tissue consisted of lacunas of different sizes. The inner wall of the lumen was lined with monolayer of flat endothelial cells. The cavity contained a few lymphocytes. The interstitial between the erythrocytes and the lacuna was composed of collagen fibers, Lymphocyte accumulation. Immunohistochemistry: The tumor cells D2-40 (+), CD31, CD34, EMA, SMA, CK5 / 6 and calretinin were both (-). Conclusion Adrenal cavernous lymphangioma is a benign tumor of the lymphatic system. Its characteristic histomorphology and immunohistochemical phenotype are helpful for the diagnosis and differential diagnosis.