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目的观察噻托溴铵联合桉柠蒎治疗慢性阻塞性肺疾病急性加重期治疗效果。方法选择2013年7月-2015年9月石家庄医学高等专科学校附属医院住院治疗的慢性阻塞性肺疾病急性加重期患者86例,随机分为试验组与对照组各43例,2组患者均采用吸氧、抗感染常规治疗。试验组加用噻托溴铵联合桉柠蒎肠溶软胶囊;对照组加用盐酸氨溴素口服液,2组均以7d为1个疗程。1个疗程后评价临床治疗效果并对2组患者治疗前后的肺功能各参数进行比对。结果试验组总有效率97.68%明显优于对照组的83.72%,差异有统计学意义(P<0.05)。2组治疗后肺功能均较治疗前改善,试验组改善优于对照组,差异有统计学意义(P<0.05)。试验组出现轻度口干不良反应4例、对照组3例,差异无统计学意义(P>0.05)。结论噻托溴铵联合柠蒎肠溶软胶囊配用常规抗感染治疗慢性阻塞性肺疾病急性加重有显著的疗效,且使用安全。
Objective To observe the curative effect of tiotropium combined with eucalyptol and pinene in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods From July 2013 to September 2015, 86 cases of acute exacerbation of chronic obstructive pulmonary disease hospitalized in Shijiazhuang Medical College Affiliated Hospital were randomly divided into experimental group and control group, 43 cases each. Both groups were used Oxygen, anti-infective routine treatment. Experimental group plus tiotropium combined eucalyptus lemon pine enteric soft capsules; control group plus ammonia bromine oral solution, two groups were 7d for a course of treatment. After a course of treatment to evaluate the clinical effect of treatment and two groups of patients before and after treatment of lung function parameters were compared. Results The total effective rate in experimental group was significantly higher than that in control group (97.68% vs 83.72%, P <0.05). The lung function of the two groups improved compared with that before treatment, and the improvement in the experimental group was better than that in the control group, with significant difference (P <0.05). There were 4 mild dyspepsia patients in the test group and 3 in the control group, with no significant difference (P> 0.05). Conclusions Tiotropium combined with lemon pine enteric soft gelatin capsules with conventional anti-infection treatment of acute exacerbation of chronic obstructive pulmonary disease have a significant effect, and safe to use.