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自1972年Magnius和Espmark等首先发现e抗原以来,人们对它的纯化方法、理化特性、检测方法以及其临床和流行病学的意义进行了大量的研究,但对e抗原的本质仍然不清楚。本文将集中地对近年来关于e抗原本质的一些研究,作一简要的综述。一、e抗原可能是宿主机体对乙型肝炎病毒感染反应的产物。 Magnius等开始考虑e抗原是宿主被病毒感染时分离出来的一种抗原,但又不象是由于肝脏损害时从肝细胞释放出来的宿主结构。由于这种抗原在甲型肝炎的病例中从未发现过,因此进而考虑e抗原可能对乙型肝炎病毒是特异的,或是宿主对病毒反应而产生的。以后通过流行病学的研究,证明e抗原出现在乙型肝炎的潜伏期,但这并不意
Since the first discovery of e antigen by Magnius and Espmark in 1972, many studies have been conducted on the purification methods, physical and chemical properties, detection methods and their clinical and epidemiological significance. However, the nature of e antigen remains unclear. This article will focus on some of the recent studies on the nature of e antigen, a brief review. One, e antigen may be the host body of hepatitis B virus infection reaction product. Magnius et al. Began to consider that e antigen is an antigen that is isolated when a host is infected by a virus but not as a host structure released from liver cells upon liver damage. Since this antigen has never been found in the hepatitis A cases, it is further considered that the e antigen may be specific to hepatitis B virus or generated by the host in response to the virus. Later, through epidemiological studies, e antigen showed that the incubation period of hepatitis B, but this does not mean