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目的:分析分娩方式与新生儿外周血淋巴细胞、免疫球蛋白之间的关系。方法:将2009年4月至2010年6月我院产科出生的孕母健康的新生儿根据分娩方式分为阴道产组(n=92)和剖宫产组(n=76),于生后2～4 d采集外周静脉血,分析其淋巴细胞、免疫球蛋白组成。结果:与阴道产组相比,剖宫产组新生儿外周血淋巴细胞中CD3+和CD4+的百分比均显著下降(P<0.05);而CD8+细胞及NK细胞(自然杀伤细胞)下降不明显,CD4+/CD8+值无明显变化(P>0.05)。剖宫产组新生儿外周血免疫球蛋白IgA、IgM的含量均明显增高(P<0.05),而IgG含量在两组间差异无统计学意义(P>0.05)。结论:不同分娩方式对新生儿外周血特异性细胞免疫影响不大。
Objective: To analyze the relationship between mode of delivery and peripheral blood lymphocytes and immunoglobulins in neonates. Methods: The healthy pregnant newborn infants born in obstetrics from April 2009 to June 2010 were divided into vaginal delivery group (n = 92) and cesarean section group (n = 76) according to mode of delivery. After birth Peripheral venous blood was collected from 2 to 4 days, and the lymphocytes and immunoglobulins were analyzed. Results: Compared with the vaginal delivery group, the percentage of CD3 + and CD4 + in neonates with cesarean section was significantly decreased (P <0.05), while the CD8 + cells and natural killer cells (NK cells) / CD8 + value had no significant change (P> 0.05). The contents of immunoglobulin IgA and IgM in neonates with cesarean section were significantly increased (P <0.05), but there was no significant difference in IgG content between the two groups (P> 0.05). Conclusion: Different modes of delivery have little effect on the specific cellular immunity of the newborn.