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环丙基-2-氟苄基酮经氯代得到2-氯-1-环丙基-2-(2-氟苯基)乙酮,然后与5,6,7,7-四氢噻吩并[3,2-c]吡啶-2(4H)-酮对甲苯磺酸盐进行偶联反应制得5-(-环丙羰基-2-氟苄基)-2-氧代-4,5,6,7-四氢噻吩并[3,2-c]吡啶,最后经乙酰化反应制得普拉格雷,总收率46%。
Cyclopropyl-2-fluorobenzyl ketone is chlorinated to give 2-chloro-1-cyclopropyl-2- (2-fluorophenyl) ethanone and then with 5,6,7,7-tetrahydrothieno The coupling reaction of [3,2-c] pyridin-2 (4H) -one p-toluenesulfonate gave 5 - (- cyclopropylcarbonyl-2-fluorobenzyl) Tetrahydrothieno [3,2-c] pyridine, and finally prasugrel obtained by acetylation, the total yield of 46%.