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目的:检测β-连环蛋白(β-catenin)在毛母质瘤及毛发上皮瘤中的表达。方法:应用免疫组织化学法检测20例正常皮肤、20例毛母质瘤及10例毛发上皮瘤中β-连环蛋白的表达。结果:β-连环蛋白在正常皮肤角质形成细胞中主要表达于细胞膜,15例毛母质瘤和8例毛发上皮瘤的表达位于胞质和/或胞核。结论:β-连环蛋白可能参与毛基质细胞的增殖和成熟的调控,它的异常表达在毛囊发育和向毛囊分化肿瘤的发生中可能起重要作用。
Objective: To detect the expression of β-catenin in hairy cells and hair tumors. Methods: The expression of β-catenin in 20 cases of normal skin, 20 cases of hair tumor and 10 cases of hair epithelial tumor were detected by immunohistochemistry. Results: β-catenin was mainly expressed in the cell membrane in normal skin keratinocytes. The expression of 15 cases of hairy tumor and 8 cases of hair epithelial tumors were located in the cytoplasm and / or nucleus. CONCLUSION: β-catenin may be involved in the regulation of proliferation and maturation of hair stromal cells. The abnormal expression of β-catenin may play an important role in the development of hair follicles and the development of hair follicle differentiated tumors.