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We investigate the dynamical behavior of hybrid virus infection systems with nonlytic immune response in switching environment,which is modeled as a stochastic process of telegraph noise and represented as a multi-state Markov chains.Firstly,The existence of unique positive solution and boundedness of the new hybrid system is proved.Furthermore,the sufficient conditions for extinction and persistence of virus are established.Finally,stochastic simulations are performed to test and demonstrate the conclusions.As a consequence,our work suggests that stochastic switching environment plays a crucial role in the process of virus prevention and treatment.