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布氏菌S_(105)菌苗是将S_2菌用化学诱变方法研制成功的新菌苗。经豚鼠实验证明其毒力更低,有良好的免疫源性、稳定性和免疫效果。对家畜也有较好的免疫效果。为了进一步了解S_(105)苗免疫后对体内组织的影响,作了S_(105)苗免疫羊的病理学观察。1 材料和方法 实验用怀孕羊48只,以随机抽样法分为免疫组和攻毒对照组。其中免疫组33只,攻毒组15只。将S_(105)的48小时纯培养物制成100亿/ml的活菌液,每只灌服1ml。免疫组羊于免疫后2个月连同对
The Brucella S_ (105) bacterin is a new bacterin which has successfully developed the bacterium S_2 by chemical mutagenesis. Guinea pig experiments proved its virulence is lower, with good immunogenicity, stability and immune effects. Livestock also have a better immune effect. In order to further understand the effect of S_ (105) vaccine on the in vivo tissues, the pathological observation of sheep immunized with S_ (105) seedlings was made. MATERIALS AND METHODS: Forty-eight pregnant sheep were randomly divided into immunization group and challenge control group. 33 in the immunized group and 15 in the challenged group. 48 hours of pure culture of S_ (105) was made into 10 billion / ml of live bacteria solution, each dosing 1ml. Immunized groups of sheep 2 months after immunization with the right