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黄曲霉毒素 B_1(AFB_1) 与原发性肝癌的关系十分密切,黄曲霉毒素 M_1(AFM_1) 是机体摄入 AFB_1后产生的主要代谢产物之一。我们对广西肝癌高发区30名1～12个月龄的婴儿进行尿中 AFM_1的检测,以了解肝癌高发区婴儿尿中 AFM_1的含量及排出水平。结果:肝癌高发区婴儿尿中 AFM_1的检出率为73. 33%;肝癌高发区婴儿从尿中排出的AFM_1是相对低发区婴儿的4. 65倍(P<0. 005) ;女性婴儿从尿中排出的 AFM_1是男性婴儿的4. 72倍(P<0. 005) 。
Aflatoxin B_1 (AFB_1) is closely related to primary liver cancer. Aflatoxin M_1 (AFM_1) is one of the main metabolites produced by AFB_1 in vivo. We investigated the urine AFM_1 in 30 infants aged 1 to 12 months with high incidence of HCC in Guangxi in order to understand the contents and levels of AFM_1 in infants with high incidence of HCC. Results: The detection rate of AFM_1 in infants with high incidence of HCC was 73.33%. The incidence of AFM_1 in infants with HCC was 4.65 times higher than that in infants with low incidence (P0.005). The female infants AFM_1 from urinary excretion was 4.72 times more than that of male infants (P <0. 005).