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本文报道用环磷酰胺治疗并发膀胱炎病例。自1976～1985年,有23例证实为应用环磷酰胺治疗后发生膀胱炎。根据环磷酰胺治疗史及膀胱镜所见粘膜与粘膜下典型形态而确诊。经静脉肾盂造影(IVP)与膀胱尿道造影评价尿路解剖学。确定初始膀胱炎疗效及有无反复出血。鉴别环磷酰胺对尿路的其它影响,包括肾盂积水、膀胱输尿管返流、膀胱挛缩、失禁等,并提供治疗结果。结果 23例诊断为各种疾病,包括实体肿瘤与淋巴增殖性疾病。男7例,女16例,年龄3～24岁。18例除用环磷酰胺外亦受腹部和/或盆腔放疗,仅5例单用环磷酰胺。出现肉眼血尿及膀胱刺激症状时对尿路进行评价,示膀胱输尿管返流9例(39％),肾盂积水4例(17％),膀胱挛缩3例(13％)。7例肾
This article reports the treatment of cystitis with cyclophosphamide cases. From 1976 to 1985, 23 cases confirmed cystitis after treatment with cyclophosphamide. According to the history of cyclophosphamide and cystoscopy see mucosal and submucosal typical morphology and confirmed. Urinary tract anatomy was evaluated by intravenous pyelography (IVP) and cystocegreography. Determine the initial cystitis efficacy and whether the repeated bleeding. Identify other effects of cyclophosphamide on the urinary tract, including hydronephrosis, vesicoureteral reflux, bladder contracture, incontinence, and provide treatment outcomes. Results 23 cases were diagnosed as various diseases, including solid tumors and lymphoproliferative diseases. 7 males and 16 females, aged 3 to 24 years old. 18 patients were treated with cyclophosphamide in addition to abdominal and / or pelvic radiotherapy, only 5 cases of cyclophosphamide alone. Urethral conditions were evaluated when gross hematuria and bladder irritation occurred, including 9 cases of vesicoureteral reflux (39%), 4 cases of hydronephrosis (17%) and 3 cases of bladder contracture (13%). 7 cases of kidney