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目的 探讨阿托伐他汀 (立普妥 )与氟伐他汀 (来适可 )对高胆固醇血症病人疗效及安全性。方法 10 0例高胆固醇血症随机分成阿托伐他汀组 5 0例和氟伐他汀组 5 0例 ,治疗 6周后观察比较。结果 阿托伐他汀及氟伐他汀均能明显降低TC、TG、LDL C水平 (P <0 0 1或P <0 0 5 ) ,阿托伐他汀降TC、TG、LDL C的作用强于氟伐他汀 (P <0 0 5 ) ,两药均能升高HDL C水平 (P <0 0 5 ) ,但两组比较未达到显著差异 (P >0 0 5 )。两药不良反应均比较小 ,耐受性好。结论 阿托伐他汀降TC、TG、LDL C的作用优于氟伐他汀 ,但升高HDL C水平相似 ,两药均有良好的安全性。
Objective To investigate the efficacy and safety of atorvastatin (Lipitor and fluvastatin) in patients with hypercholesterolemia. Methods A total of 100 cases of hypercholesterolemia were randomly divided into atorvastatin group 50 cases and fluvastatin group 50 cases. After 6 weeks of treatment, the observation and comparison were made. Results Both atorvastatin and fluvastatin significantly decreased the levels of TC, TG and LDL C (P <0.01 or P <0.05), and the effects of atorvastatin on TC, TG and LDL C were stronger than those of fluoride Both statins (P <0 05) showed that both drugs increased HDL C level (P <0.05), but no significant difference was found between the two groups (P> 0.05). Adverse reactions of both drugs are relatively small, well tolerated. Conclusions Atorvastatin is superior to fluvastatin in reducing TC, TG and LDL C levels, but raising HDL C level is similar. Both drugs have good safety.