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目的探讨2型糖尿病合并血管闭塞性病变的危险因素。方法将213例2型糖尿病患者分为糖尿病合并血管闭塞性病变(DA)组和非合并血管闭塞性病变(NDA)组,比较两组之间的性别、年龄、病程、吸烟史、体重指数(BMI)、血糖(PG)、血脂、胰岛素(Ins)、C肽(CP)、血尿酸(UA)、胰岛素抵抗指数等指标,并采用Logistic回归分析2型糖尿病患者合并血管闭塞性病变组的相关危险因素。结果 DA组患者年龄、糖尿病病程、吸烟史、颈围、腰围、臀围、BMI、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、糖化血红蛋白(HbA1C)、尿酸(UA)、血糖、胰岛素、C肽、胰岛素抵抗指数(HOMA-IR)较NDA组明显升高(P<0.05),Logistic回归分析显示,2型糖尿病合并血管闭塞性病变的独立危险因素分别为HOMA-IR、吸烟、TC、病程、HbA1C、BMI和UA。结论胰岛素抵抗、吸烟、高胆固醇、病程、高HbA1C、肥胖和高尿酸血症是2型糖尿病合并血管闭塞性病变的危险因素。
Objective To investigate the risk factors of type 2 diabetes with vascular occlusive disease. Methods 213 patients with type 2 diabetes mellitus were divided into two groups: diabetes mellitus with vascular occlusive disease (DA) group and non-combined vascular occlusive disease (NDA) group. The gender, age, course of disease, smoking history, body mass index BMI, PG, lipids, Ins, C peptide, UA, and insulin resistance index were analyzed. Logistic regression analysis was used to analyze the association between type 2 diabetes mellitus patients with vascular occlusive disease Risk factors. Results The age, duration of diabetes, smoking history, neck circumference, waist circumference, hip circumference, BMI, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), glycosylated hemoglobin (HbA1C) UA, blood glucose, insulin, C-peptide and insulin resistance index (HOMA-IR) were significantly higher than those in NDA group (P <0.05). Logistic regression analysis showed that independent risk factors of type 2 diabetes mellitus with vascular occlusive disease were HOMA-IR, smoking, TC, duration of disease, HbA1C, BMI and UA. Conclusion Insulin resistance, smoking, high cholesterol, duration of disease, high HbA1C, obesity and hyperuricemia are risk factors for type 2 diabetes with vascular occlusive disease.