应用MR动脉自旋标记技术早期鉴别诊断早老性阿尔茨海默病与额颞叶痴呆

• 作 者: R.M.E.Steketee E.E.Bron R.Meijboom G.C.Houston S.Klein H.J.M.M.Mutsaerts 娄炎燚
• 机 构: Department of Radiology, Erasmus MC -University Medical Center,
• 出 处: 国际医学放射学杂志
• 发表日期: 2016年02期
• 关键词: 动脉自旋标记 额颞叶痴呆 阿尔茨海默病 MR 脑灌注 脑血流量 早老性痴呆 鉴别诊断 年龄相关性 容积效应

摘要目的研究MR动脉自旋标记技术(ASL)对于两种最为常见的早老性痴呆,即阿尔茨海默病(AD)和额颞叶痴呆(FTD)的早期诊断、早期鉴别,并对年龄相关性脑灌注异常与病理性脑灌注异常进行鉴别。方法 AD组13例,FTD组19例,老年对照组25例,年轻对照组22例,均行3.0 T MR3D-ASL扫描。部分容积效应校正后,测量整个幕上皮质的10个灰质区的脑灰质体积(GM)、脑血流量(CBF)。对病人组

Abstract Objective To investigate the early diagnosis and early identification of two most common Alzheimer’s disease (AD) and frontotemporal dementia (FTD) in MR arterial spin labeling (ASL) Cerebral perfusion abnormalities and pathological cerebral perfusion abnormalities were identified. Methods Thirteen patients in AD group, 19 in FTD group, 25 in elderly control group and 22 in young control group were performed 3.0 T MR3D-ASL scan. After partial volume effect correction, gray matter volume (GM) and cerebral blood flow (CBF) were measured in 10 gray matter regions of the entire supratentorial cortex. To patient group