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目的研究胃癌组织中基质细胞因子-1(stromal derived factor-1,SDF-1)及其受体(CXC chemokine receptor 4,CXCR4)的表达,探讨SDF-1/CXCR4轴与血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的关系及其与胃癌浸润转移的相关性。方法采用免疫组织化学法检测62例胃癌患者的胃癌组织及癌旁组织中SDF-1,CXCR4及VEGF的表达情况。结果胃癌组织中SDF-1,CXCR4及VEGF的阳性表达率分别为85.4%,58.1%,62.9%,均高于癌旁组织45.2%,38.7%,35.5%,差异有统计学意义(P<0.05);SDF-1及CXCR4的表达水平在肿瘤病理分级、TNM分期、淋巴结及远处脏器转移上差异有统计学意义(P<0.05);SDF-1,CXCR4的表达与VEGF均呈正相关(r=0.394,P<0.05;r=0.526,P<0.05)。结论 SDF-1/CXCR4轴及VEGF在胃癌的生长、浸润、转移中发挥重要作用,可能成为未来药物治疗胃癌的重要靶点。
Objective To investigate the expression of stromal derived factor-1 (SDF-1) and its receptor (CXCR4) in gastric cancer and to explore the relationship between SDF-1 / CXCR4 axis and vascular endothelial growth factor Relationship between the expression of VEGF and the infiltration and metastasis of gastric cancer. Methods Immunohistochemistry was used to detect the expression of SDF-1, CXCR4 and VEGF in gastric cancer tissues and adjacent non-cancerous tissues from 62 patients with gastric cancer. Results The positive rates of SDF-1, CXCR4 and VEGF in gastric cancer tissues were 85.4%, 58.1% and 62.9%, respectively, which were significantly higher than those in adjacent tissues (45.2%, 38.7%, 35.5%, P <0.05) ). The expressions of SDF-1 and CXCR4 were significantly different between tumor pathological grade, TNM stage, lymph node and distant organs metastasis (P <0.05) r = 0.394, P <0.05; r = 0.526, P <0.05). Conclusion SDF-1 / CXCR4 axis and VEGF play an important role in the growth, invasion and metastasis of gastric cancer, which may be an important target for future drug treatment of gastric cancer.