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交流电示波极谱法与普通极谱法都可用以测定舍可那。其方法简便可靠,适于药物分析之用。 1.用交流电示波极谱法与pH9硼砂缓冲底液时,在舍可那示波图的阴极支上有一显著切口,25℃时,测得切口电位为-1.14伏(S.C.E.)(Q=0.52)。当分析液浓度大于1.6×10~(-3)M时,阳极支上也出现一切口,其电位为-0.94伏(S.C.E.)(Q=0.43)。浓度在2×10~(-4)M～4.8×10~(-3)M范围内,可根据阴极支的切口高度测定此种化合物。下列四种现象都证明舍可那的电极过程是吸附控制的:(1)升高温度时,其切口缩短。(2)5×10~(-3)M分析液的示波图的高度约为空白底液的两倍。(3)加入明胶后,其切口消失。(4)此种化合物能显著地妨碍二价铅离子切口的出现。实验证明,舍可那的水溶液稳定性良好,可用作含水制剂。将舍可那溶于生理食盐水中制成溶液,经连续观察结果,证明其稳定性良好。因此可制成舍可那生理食盐水注射液。 2.用普通极谱法与0.05M硼砂底液时,无阴极波产生,但有一阳极波出现,25℃时,E_(1/2)=+0.03伏(S.C.E.)。浓度在6×10~(-5)M～2×10~(-4)M范围内,其波高与浓度成线性关系。若分析液的浓度大于2×10~(-4)M时,则波高为一常数。此外尚证明了此种极谱电流是扩散控制的。
AC oscillopolarography and conventional polarography can be used to determine Shekina. The method is simple and reliable, suitable for drug analysis purposes. 1. With oscillopolarography and pH9 borax buffer bottoms, there was a significant incision in the Siena chart of the cathodic branch and a cut-off potential of -1.14 volts (SCE) was measured at 25 ° C (Q = 0.52). When the concentration of the analyte was more than 1.6 × 10 -3 M, there was also a notch in the anode branch with a potential of -0.94 V (Q = 0.43). Concentrations in the range of 2 × 10 -4 M to 4.8 × 10 -3 M can be measured according to the height of the cathodic branch incision. The following four phenomena all prove that the Schönau’s electrode process is adsorption controlled: (1) The cut is shortened at elevated temperature. (2) The height of the oscillogram of 5 × 10 ~ (-3) M analysis solution is about twice that of the blank solution. (3) After adding gelatin, the incision disappeared. (4) Such a compound can significantly hinder the appearance of a divalent lead ion cut. Experiments show that Shek satisfied that the aqueous solution of good stability, can be used as an aqueous preparation. She would be soluble in saline to make a solution, after continuous observation of the results to prove its good stability. It can be made Shekina physiological saline injection. 2. When using normal polarography with 0.05M borax solution, no cathodic wave was produced but an anodic wave appeared. At 25 ℃, E 1/2 (1/2) = + 0.03V (S.C.E.). The concentration was in the range of 6 × 10 ~ (-5) M ~ 2 × 10 ~ (-4) M, and the wave height was linear with the concentration. If the analyte concentration is more than 2 × 10 -4 M, the wave height is constant. In addition it is proved that this polarographic current is diffusion-controlled.