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目的:观察纳洛酮治疗新生儿缺氧缺血性脑病的临床疗效及分析。方法:选择68例缺氧缺血性脑病患儿,随机分为对照组和观察组,两组均34例,对照组采取常规综合治疗,观察组在对照组治疗基础上给予纳洛酮静脉滴注治疗。结果:两组的NBNA评分与治疗前比较,均显著下降(P<0.01),治疗后两组NBNA评分组间比较,观察组明显优于对照组(P<0.05)。两组总有效率比较,P<0.05,观察组明显优于对照组。结论:纳洛酮治疗新生儿缺氧缺血性脑病,可以明显改善患儿症状及神经功能,值得应用。
Objective: To observe the clinical effect and analysis of naloxone on neonatal hypoxic-ischemic encephalopathy. Methods: Sixty-eight children with hypoxic-ischemic encephalopathy were randomly divided into control group and observation group, 34 cases in both groups. The control group was treated with routine combination therapy. The observation group received naloxone intravenously Note treatment. Results: NBNA score decreased significantly in both groups compared with those before treatment (P <0.01). After treatment, NBNA score of the two groups was significantly better than that of the control group (P <0.05). The total effective rate between the two groups, P <0.05, the observation group was significantly better than the control group. Conclusion: Naloxone treatment of neonatal hypoxic-ischemic encephalopathy, can significantly improve children’s symptoms and neurological function, it is worth applying.