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目的探讨清肝利湿汤联合拉米夫定治疗肝胆湿热型乙型肝炎的临床疗效。方法选取2013年3月至2015年3月符合诊断标准的肝胆湿热型乙型肝炎患者64例,依据治疗方案分为两组,每组32例。联合组采用中药清肝利湿汤联合拉米夫定治疗,单药组口服拉米夫定治疗,比较两组临床治疗效果。结果治疗后,联合组证候疗效(81.25%)优于单药组(59.38%),差异有统计学意义(P<0.05);ALT复常率、HBV-DNA转阴率、Hbe Ag转阴率及Hbe Ag/HBe Ab血清转换率均高于单药组,差异有统计学意义(P<0.05);联合组丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素、HBV-DNA水平下降程度大于单药组,差异有统计学意义(P<0.05)。结论清肝利湿汤联合拉米夫定治疗肝胆湿热型乙型肝炎疗效显著,值得临床推广。
Objective To investigate the clinical efficacy of Qinggan Lishi Decoction combined with lamivudine in the treatment of hepatitis B and Damp-heat hepatitis. Methods Sixty-four patients with hepatobiliary-cholestatic hepatitis B who met the diagnostic criteria from March 2013 to March 2015 were divided into two groups (32 in each group) according to the treatment plan. The combination group was treated with Qinggan Lishi Decoction combined with lamivudine, and the single drug group was treated with lamivudine orally, and the clinical effects were compared between the two groups. Results After treatment, the curative effect of syndrome in combination group (81.25%) was superior to that of monotherapy group (59.38%), the difference was statistically significant (P <0.05). The ALT normalization rate, HBV- (P <0.05). The combination of alanine aminotransferase, aspartate aminotransferase, total bilirubin, The level of HBV-DNA decreased more than single drug group, the difference was statistically significant (P <0.05). Conclusion Qingganli Decoction combined with lamivudine treatment of hepatobiliary and damp-heat hepatitis B has significant curative effect, which is worthy of clinical promotion.