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在日本Jinzu流域镉污染区选择69名30岁以上的妇女,分为三个接触组:A组为19名骨痛病患者;B组为21名可疑患者(仅有肾损害,无明显的骨损害);C组为29名无任何异常表现的污染区居民。另外在无镉污染的金泽城选择31名妇女作对照(D组)。使用无火焰原子吸收法测定血清和尿铜、锌含量,用放射免疫法测定β_2-微球蛋白含量,各项检查结果用几何均数表示。结果如下:
Sixty-nine women over the age of 30 were selected for inclusion in the cadmium-contaminated area of the Jinzu catchment in Japan and divided into three exposure groups: 19 patients with bone pain in group A; 21 suspicious patients in group B (renal impairment only, no visible bone Damage); Group C was 29 residents without any abnormalities in the polluted area. In addition, 31 women were selected as controls in Kanazawa Castle without cadmium contamination (Group D). Non-flame atomic absorption spectrometry was used to determine the contents of copper and zinc in serum and urine, and the content of β_2-microglobulin was determined by radioimmunoassay. The results of each test were expressed as geometric mean. The result is as follows: