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粉防己碱是北豆根所含主要有效成分之一，为了解药动学和药效学的关系，本文选择灵敏度高，选择性强的胶束荧光法，研究了粉防己碱在兔体内的药代动力学。实验结果表明，粉防己碱是一种中速吸收，中速消除的药物，其几个主要药动学参数为ｔ１／２（α）为１．４ｈ，ｔ１／２（β）为５．１８７ｈ、ｔ１／２（Ｋａ）为１．３１４ｈ、Ｋ２１为０．４３１２ｈ－１、Ｋ１０为０．１５３４ｈ－１、Ｋ１２为０．０４４ｈ－１、ＡＵＣ为１０５．７μｇ·ｈ·ｍｌ－１。
Tetrandrine is one of the main active ingredients contained in the root of Peach. To understand the relationship between pharmacokinetics and pharmacodynamics, this paper chooses the micellar fluorescence method with high sensitivity and selectivity to study the effect of tetrandrine in rabbits Pharmacokinetics. The experimental results show that tetrandrine is a medium-speed absorption, medium-speed elimination of the drug, the main pharmacokinetic parameters t1 / 2 (α) of 1.4h, t1 / 2 (β) of 5.187h , T1 / 2 (Ka) was 1.314 h, K21 was 0.4312 h-1, K10 was 0.1534 h-1, K12 was 0.044 h-1, and AUC was 105.7 μg · h · ml-1.