Interactive Study between Two Types of 1—[2—（Hydroxyethoxy）methyl] —6—naphthylmethylthymines and HIV

• 作 者: 孟歌 陈芬儿 De Clercq Erik 戴惠芳
• 机 构: DepartmentofChemistry,RegaInstituteforMedicalResearch
• 出 处: 过程工程学报
• 发表日期: 2003年1期
• 关键词: 艾滋病毒 HIV-1 逆转录敏 6萘基HEPT类似物 自由结合能 抗病毒活性 HIV-1 reverse transcriptase binding free

Two different types of 1-[2-(hydroxyethoxy)methyl]-6-naphthylmethylthymines have been designed, synthesized and evaluated for their anti-HIV-1 activities in different cells lines. The binding free energy ((G) including steric and electrostatic between the