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目的：观察乙酰酸胆硷酯酶在脑缺血损伤中的作用及作用机理。方法：采用大鼠颈总动脉闭塞性休克模型，测定大鼠海马结构内MDA的含量及SOD、AChE的活性。统计学处理采用t检验。结果：休克组与对照组比较，海马组织MDA含量升高，SOD活性降低，AChE光密度明显升高。结论：①脑缺血后迅速发生了组织低灌流及神经细胞膜功能损害。②AChE不仅参与胆硷能神经递质的传递，还可能参与了脑缺血早期对神经元损伤的保护作用。
Objective: To observe the effect and mechanism of acetylcholine cholinesterase in cerebral ischemia injury. Methods: The rat model of common carotid artery occlusive shock was used to measure the content of MDA and the activity of SOD and AChE in rat hippocampal formation. Statistical analysis using t test. Results: Compared with the control group, the content of MDA and the activity of SOD in the hippocampus of shock group were decreased, and the optical density of AChE was significantly increased. Conclusions: ①The tissue hypoperfusion and the damage of nerve cell membrane rapidly occur after cerebral ischemia. ② AChE not only participates in the transmission of cholinergic neurotransmitter, but also may participate in the protective effect of neuronal injury in the early stage of cerebral ischemia.