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目的:研究局部晚期食管鳞状细胞癌术后放化疗对患者生存率的影响研究。方法:选择我院2009年1月~2012年1月经根治术后病理学检查确诊的局部晚期食管鳞状细胞癌患者150例,按知情同意原则分成单纯放疗组(48例)、单纯化疗组(54例)、放化疗组(48例)三组,单纯放疗组于术后6周内用15MV-X线照射,总剂量50Gy/25f,治疗30天。单纯化疗组于术后4周内开始用DDP和5-Fu联合方案进行序贯性化疗,放化疗组的剂量同单纯放疗组和单纯化疗组。结果:三组患者治疗有效率分别为72.91%、51.85%、91.67%,差别有统计学意义(P<0.05),三组患者的三年生存率组间差别有统计学意义(P<0.05),放化疗组患者治疗有效率及三年生存率最高。结论:局部晚期食管鳞状细胞癌术后应用放化疗作为辅助治疗手段疗效较单纯化疗和单纯放疗好。
Objective: To study the effect of postoperative radiochemotherapy on the survival rate of locally advanced esophageal squamous cell carcinoma. Methods: A total of 150 patients with locally advanced esophageal squamous cell carcinoma diagnosed by radical mastectomy from January 2009 to January 2012 in our hospital were divided into radiotherapy group (n = 48), chemotherapy alone group (n = 54 cases) and radiotherapy and chemotherapy group (48 cases). The radiotherapy group was treated with 15MV-X radiation within 6 weeks after operation and the total dose was 50Gy / 25f for 30 days. The chemotherapy alone group started sequential chemotherapy with DDP and 5-Fu combination within 4 weeks after surgery. The dose of radiotherapy and chemotherapy group was the same as that of radiotherapy group and chemotherapy alone group. Results: The effective rates of the three groups were 72.91%, 51.85% and 91.67%, respectively, with statistical significance (P <0.05). The three-year survival rates of the three groups were statistically significant (P <0.05) , Radiotherapy and chemotherapy patients with effective treatment and the highest three-year survival rate. Conclusion: The application of chemoradiotherapy as adjuvant therapy for locally advanced esophageal squamous cell carcinoma is more effective than chemotherapy and radiotherapy alone.