Radix Ilicis Pubescentistotal lfavonoidsameliorates neuronal damage and reduces lesion extent in a m

• 作 者: Ming-san Miao Lin Guo Rui-qi Li Xiao-lei Zhang
• 机 构: College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, Ch
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2016年3期
• 关键词: nerve regeneration transient ischemic attack Radix Ilicis Pubescentis total flav

Flavonoids are a major component in the traditional Chinese medicine RadixIlicis Pubescentis. Previous studies have shown that the administration of RadixIlicis Pubescentis total lfavonoids is protective in cerebral ischemia. However, to our knowledge, no studies have examined whether the total lfavonoids extracted from RadixIlicis Pubescentis prevent or ameliorate neuronal damage following transient ischemic attacks. Therefore, RadixIlicis Pubescentis total lfavonoids question and the potential underlying mechanisms. Thus, beginning 3 days before the induction of a mouse model of transient ischemic attack using tert-butyl hydroperoxide injections, mice were intragas-trically administered 0.3, 0.15, or 0.075 g/kg of RadixIlicis Pubescentis total lfavonoids daily for 10 days. The results of spectrophotometric analyses demonstrated that RadixIlicis Pubescentis total lfavonoids enhanced oxygen free radical scavenging and reduced pathological alter-ations in the brain. Hematoxylin-eosin staining results showed that RadixIlicis Pubescentis total lfavonoids reduced hippocampal neuronal damage and cerebral vascular injury in this mouse model of transient ischemic attack. These results suggest that the antioxidant effects of RadixIlicis Pubescentis total lfavonoids alleviate the damage to brain tissue caused by transient ischemic attack.