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目的测定肝硬化患者血清瘦素水平,并探讨其在肝硬化发病过程中的意义。方法采用放射免疫法测定56例肝硬化患者和30例对照者血清瘦素和肝纤维化血清学指标:透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)和层粘蛋白(LN)的水平,同时做肝脏病理活检。结果肝硬化患者的血清瘦素水平和HA、Ⅳ-C、LN均显著高于对照组(P<0.01),且瘦素水平与Child-Pugh分级有关(P<0.01),和HA、Ⅳ-C、LN呈正相关(P<0.01)。结论肝硬化患者的血清瘦素水平明显升高,其可能与肝纤维化的发展相关。
Objective To determine the level of serum leptin in patients with cirrhosis and to explore its significance in the pathogenesis of cirrhosis. Methods Serum leptin and hepatic fibrosis were measured by radioimmunoassay in 56 patients with cirrhosis and 30 controls. The serum levels of HA, Ⅳ-C and laminin Level, while doing liver biopsy. Results The levels of serum leptin, HA, Ⅳ-C and LN in patients with cirrhosis were significantly higher than those in control group (P <0.01), and the levels of serum leptin were correlated with Child-Pugh classification (P <0.01) C, LN (P <0.01). Conclusion Serum leptin levels in patients with cirrhosis are significantly increased, which may be related to the development of liver fibrosis.