【摘 要】
：
A series of poly(ether-amide) dendrimers with amino acids and peptides as the peripheral functional groups was synthesized, and their structures were confirmed
【机 构】
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Key Laboratory of Drag Targeting of Ministry of Education, West China School of Pharmacy, Sichuan Un
论文部分内容阅读
A series of poly(ether-amide) dendrimers with amino acids and peptides as the peripheral functional groups was synthesized, and their structures were confirmed by nuclear magnetic resonance (NMR) and electrospray ioniza-tion-mass spectrometry (ESI-MS) spectrometry. Molecular dynamics simulation of the peptide dendrimers in solution was performed, indicating that, the prior conformations of the dendrimers were atom number dependent, I.e., with the increases of the atom number, the prior conformations were more spherical. Also, the amino acid a-C atom radial distribu-tion indicated that, with larger peripheral groups, more back-folding of the dendrimers occurred.
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