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目的观察乌司他丁对心肺复苏患者脑复苏的作用及其预后的影响。方法随机选择2006年10月至2008年12月45例恢复自主循环的心肺复苏患者作为研究对象,分成两组:T组在自主循环恢复后除采用常规的支持治疗外加用乌司他丁,C组采用常规的支持治疗。所有患者均在自主循环恢复后即时、复苏后1、3、7d分别进行格拉斯哥评分(GCS),同时观察患者的住院时间、机械通气时间、病死率、多脏器损害发生率等指标。结果自主循环恢复即刻、1d两组的(GCS)差异无统计学意义(P>0.05),但复苏后3、7d的(GCS)差异明显(P<0.05)。T组的住院时间、机械通气时间、病死率、多脏器损害发生率均较C组明显的减少或降低(P<0.05)。结论乌司他丁有利于心肺复苏患者的脑复苏,缩短存活患者的住院时间、保护重要脏器的功能,降低心肺复苏患者病死率,有助于改善心肺复苏患者的预后。
Objective To observe the effect of ulinastatin on cerebral resuscitation in patients with cardiopulmonary resuscitation and its prognosis. METHODS: Forty-five patients with cardiopulmonary resuscitation who underwent spontaneous circulation recovery from October 2006 to December 2008 were randomly divided into two groups: group T was treated with ulinastatin The group used routine supportive care. All patients were immediately recovered after spontaneous circulation, and the Glasgow score (GCS) was also measured at 1, 3 and 7 days after resuscitation. The hospitalization time, mechanical ventilation time, fatality rate and incidence of multiple organ damage were also observed. Results Immediate recovery of spontaneous circulation showed no significant difference on the 1st day (GCS) between the two groups (P> 0.05). However, there was a significant difference (GCS) at 3 and 7 days after resuscitation (P <0.05). The hospitalization time, mechanical ventilation time, fatality rate and the incidence of multiple organ damage in group T were significantly decreased or decreased compared with those in group C (P <0.05). Conclusion Ulinastatin is beneficial to cerebral resuscitation in patients with cardiopulmonary resuscitation, shortening the hospital stay of surviving patients, protecting the function of vital organs and reducing the mortality of patients with cardiopulmonary resuscitation, which may help to improve the prognosis of cardiopulmonary resuscitation patients.