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自噬是细胞利用细胞内溶酶体清除过量或受损的长半衰期蛋白质及细胞器的现象。自噬可通过营养剥夺适应,清除细胞内蛋白质及微细胞器等生理及病理学作用和再利用细胞废物,以维持内环境稳定、参与生长发育和疾病的发生及发展。研究发现,自噬参与了心肌肥厚、心室重构、心肌缺血/再灌注损伤等多种心血管疾病病的理生理过程。本文主要阐述自噬在正常心脏及各种常见心脏疾病中作用的研究进展,并初步探讨可能的治疗新靶点。
Autophagy is the phenomenon of cells using intracellular lysosomes to remove excess or impaired long-half-life proteins and organelles. Autophagy can be adapted through deprivation of nutrition, clear the physiological and pathological effects such as intracellular proteins and micro organelles, and recycle cellular waste to maintain the stable internal environment and participate in the development and development of diseases. The study found that autophagy involved in cardiac hypertrophy, ventricular remodeling, myocardial ischemia / reperfusion injury and other cardiovascular disease physiology and physiological processes. This article mainly expounds the research progress of the role of autophagy in normal heart and various common heart diseases, and initially explores possible new targets for treatment.