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目的对比分析妈富隆和米非司酮治疗围绝期功能失调性子宫出血(简称围绝经期功血)的临床效果。方法将166例围绝经期功血患者随机分为对照组和治疗组各83例,对照组给予米非司酮,治疗组给予妈富隆治疗。在治疗前、后分别抽血检测黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)、卵泡刺激素(follicle-stimulating hormone,FSH)和孕酮(progesterone,P)浓度,B超检查测量子宫内膜厚度。结果治疗组的治疗总有效率和显效率明显优于对照组(P<0.05);且治疗组的性激素浓度下降程度和子宫内膜变薄程度均显著优于对照组(P<0.05)。结论妈富隆治疗围绝经期功血的疗效优于米非司酮,米非司酮不宜治疗功血。
Objective To compare and analyze the clinical effect of Marvelon and mifepristone in the treatment of perioperative dysfunctional uterine bleeding (referred to as perimenopausal uterine bleeding). Methods A total of 166 patients with peri-menopausal dysfunctional uterine bleeding were randomly divided into control group and treatment group, 83 cases in each group. Mifepristone in control group and Marvelon treatment group in treatment group. Before and after treatment, blood samples were collected to measure the levels of luteinizing hormone (LH), estradiol (E2), follicle-stimulating hormone (FSH) and progesterone (P) Ultrasonography measures endometrial thickness. Results The total effective rate and markedly effective rate of the treatment group were significantly better than those of the control group (P <0.05). The levels of sex hormone and endometrial thinning in the treatment group were significantly better than those in the control group (P <0.05). Conclusion Marvelon treatment of climacteric dysfunctional uterine bleeding is better than mifepristone, mifepristone is not suitable for the treatment of dysfunctional uterine bleeding.