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目的探讨控制原发性高血压患者危险因素后血浆致动脉硬化指数(atherogenic index of plasma,AIP)的变化及意义。方法收集上海市闸北区市北医院门诊及住院的原发性高血压病患者201例,给合理的生活方式指导和严格的血压、血脂、血糖等危险因素控制,随访观察12个月,记录年龄、性别、控制前后血压、血脂、颈动脉内膜中层厚度(IMT)、血糖等检查结果。根据甘油三酯(TG)和高密度脂蛋白胆固醇(HCL-C)检测结果计算AIP。比较控制危险因素前后AIP变化与脉搏波传导速度(pulse wave velocity,PWV)、血压、血糖、血脂、IMT变化的相关性。采用SPSS17.0统计软件进行数据处理,计量资料采用均数±标准差(xˉ±s)表示,控制前后均数比较采用t检验,控制危险因素AIP值变化与各项指标的相关性采用Pearson相关分析,以AIP值变化以logistic回归分析其影响因素,以P<0.05为差异有统计学意义。结果 1控制危险因素前后AIP变化及各项指标均存在显著性差异(P<0.01)。2在控制其他相关变量的影响条件下,AIP变化分别与PWV、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、TG、IMT的变化存在正相关(P<0.05),与HCL-C存在负相关(P<0.05)。结论控制危险因素后原发性高血压患者AIP下降,可以作为动脉硬化改善的评价指标。
Objective To investigate the changes and significance of atherogenic index of plasma (AIP) in patients with essential hypertension. Methods Totally 201 patients with primary hypertension were enrolled in the outpatient department and inpatient of Shibei Hospital of Zhabei District of Shanghai. The patients were given appropriate lifestyle guidance and strict risk factors such as blood pressure, blood lipids and blood glucose. The patients were followed up for 12 months, , Sex, blood pressure before and after control, blood lipid, carotid intima-media thickness (IMT), blood glucose and other test results. AIP was calculated based on triglyceride (TG) and high-density lipoprotein cholesterol (HCL-C) test results. The changes of AIP before and after the control of risk factors were compared with the changes of pulse wave velocity (PWV), blood pressure, blood glucose, blood lipid and IMT. The data were processed by SPSS17.0 statistical software, the measurement data were expressed as mean ± standard deviation (x ± s), t test was used to compare the mean before and after control, and the correlation between the changes of risk AIP values and various indicators was analyzed by Pearson correlation Analysis, AIP value changes by logistic regression analysis of its influencing factors, P <0.05 was considered statistically significant. Results 1 There were significant differences in AIP changes before and after the control of risk factors and various indicators (P <0.01). (2) There was a positive correlation between changes of AIP and changes of PWV, TC, LDL-C, TG and IMT (P <0.05) under the influence of other related variables, -C negative correlation (P <0.05). Conclusion The decrease of AIP in patients with essential hypertension after controlling for risk factors can be used as an index to evaluate the improvement of atherosclerosis.