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目的 对严重急性呼吸综合征 (SARS)患者的相关器官功能障碍进行分析 ,探讨 SARS患者并发多器官功能障碍综合征 (MODS)的因素。方法 回顾性分析 135例 SARS和 13例并发 MODS的 SARS住院患者的临床资料。结果 SARS可导致器官功能障碍 ,主要有急性呼吸窘迫综合征 (ARDS)、免疫系统损伤、心脏损害、肝功能损害、MODS等 ,发生率越高 ,病情越重 ,病死率越高。 SARS引起 MODS时 ,病死率高达92 .3% ,主要表现为 ARDS(76 .9% )、免疫系统损伤 (92 .3% )、心血管功能障碍 (30 .8% )、凝血功能障碍(6 1.5 % )、肝功能损伤 (38.5 % )和肾功能障碍 (5 3.8% )等。结论 SARS相关器官功能障碍与病情发展及预后密切相关。 SARS并发 MODS可能与 SARS病毒所致免疫损伤、全身炎症反应综合征等有关。
Objective To analyze the related organ dysfunction in patients with severe acute respiratory syndrome (SARS) and explore the factors of multiple organ dysfunction syndrome (MODS) in patients with severe acute respiratory syndrome (SARS). Methods The clinical data of 135 SARS patients and 13 SARS patients with MODS were retrospectively analyzed. Results SARS can lead to organ dysfunction, including acute respiratory distress syndrome (ARDS), immune system injury, cardiac damage, liver damage, MODS and so on. The higher the incidence, the heavier the disease and the higher the case fatality rate. SARS caused MODS with a mortality rate of 92.3%. ARDS (76.9%), immune system damage (92.3%), cardiovascular dysfunction (30.8%), coagulation dysfunction 1.5%), liver damage (38.5%) and renal dysfunction (53.8%). Conclusion The dysfunction of SARS-related organs is closely related to the development of the disease and prognosis. SARS complicated with MODS may be associated with SARS virus-induced immune damage, systemic inflammatory response syndrome and so on.