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硫糖铝用于消化性溃疡的治疗,其疗效与甲氰咪胍相类似。晚近在治疗食管炎,预防胃肠道出血、碱性反流性胃炎等疾病有一定的疗效,现就其临床应用作一介绍。临床药理及作用机制硫糖铝是蔗糖八硫酸的碱性铝盐,几乎不溶于水,中和胃酸能力极弱,在十二指肠碱性环境时,仍然具有活性作用。在胃内酸性环境下,能离解为[Al_2(OH)_5]~+和八硫酸蔗糖阴离子复合体,后者具聚
Sucralfate is used in the treatment of peptic ulcer and its efficacy is similar to that of cimetidine. Recent treatment of esophagitis, prevention of gastrointestinal bleeding, alkaline reflux gastritis and other diseases have a certain effect, is now on its clinical application as an introduction. Clinical Pharmacology and Mechanism Sucralfate is an alkaline aluminum salt of sucrose octasulfate, is almost insoluble in water, has a very weak neutralizing acidity and has an active role in the alkaline environment of the duodenum. Under acidic conditions in the stomach, it can dissociate into [Al 2 (OH) 5] ~ + and octasulfuric acid sucrose anion complexes, which have poly