论文部分内容阅读
已证实巯基化合物能保护受低LET照射的哺乳动物细胞的损伤,其作用机理可能是:引起细胞乏氧、自由基消除及靶分子损伤修复的综合因素,这类化合物对高LET射线引起的损伤的保护作用研究较少,但它对阐明辐射防护作用机理却很重要。 WR-255591〔CH_3NH(CH_2)_3NHCH_2CH_2SH〕是氨基磷酸硫酯WR-3689的游离巯基药物,小鼠实验表明WR-2721和WR-151327能明显地防护由中子引起的致死作用,WR-255591还可降低CHO细胞的DNA损伤。
Sulfhydryl compounds have been shown to protect mammalian cells exposed to low LET. The mechanism of action may be: a combination of factors that contribute to cell hypoxia, elimination of free radicals, and target molecule damage repair. These compounds are highly damaging to high LET radiation Has little research on its protective effect, but it is very important to elucidate the mechanism of radiation protection. WR-255591 [CH_3NH (CH_2) _3NHCH_2CH_2SH] is a free sulfhydryl drug of phosphoramidothioate WR-3689. The mouse experiments show that WR-2721 and WR-151327 can obviously protect the neutrons from the lethal effect. WR- Can reduce DNA damage in CHO cells.