【摘 要】
：
Although the immunomodulatory activity of bamboo vinegar and charcoal powder (BVC) has been increasingly documented in domestic animals, the use of BVC as immunostimulant in fish aquaculture awaits verification. In the present study, the immunostimulatory
【机 构】
：
College of Animal Sciences,Zhejiang University,Hangzhou 310058,China;College of Aquaculture,Wonsan F
论文部分内容阅读
Although the immunomodulatory activity of bamboo vinegar and charcoal powder (BVC) has been increasingly documented in domestic animals, the use of BVC as immunostimulant in fish aquaculture awaits verification. In the present study, the immunostimulatory impacts of dietary BVC intake were investigated in an important aquaculture fish species, the African catfish Clarias gariepinus . Results show that the pathogen resistance of African catfish was significantly improved by dietary BVC intake at the tested levels (0.5％–2％), as indicated by higher survival rates (approximately 1.52–1.85 times that without BVC supplementation) upon intraperitoneally injection of bacterial pathogen Aeromonas hydrophila . In addition, both the count and phagocytic activity of blood cells were significantly up-regulated by a 45-day dietary supplementation of BVC. Moreover, compared to that of the control, fish individuals fed BVC containing diets exhibited significant higher activities of superoxide dismutase (SOD), myeloperoxidase (MPO), and lysozyme (LYZ). The content of immunoglobulin M (IgM) in serum of African catfish was also induced by dietary BVC supplementation. Furthermore, the expression levels of interleukin-8 ( IL - 8 ), toll-like receptor 1 and 5 ( TLR1 and TLR5 ), myeloid differentiation factor 88 ( MyD88 ), and nuclear factor kappa B ( NFκB ) in the head kidney were significantly up-regulated. Our findings indicate BVC could be an effective immunostimulant in teleost species, which may enhance fish immunity through improving hematic parameters, activating bioactive humoral molecules, and up-regulating immune related molecular pathways.
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