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近年来认为许多肺疾病的发生与发展和肺内蛋白酶—抗蛋白酶的平衡失调有关,在慢性支气管炎和肺气肿的研究中已明确了这一概念。[对人肺起作用的弹性蛋白酶的来源] 1.胰脏胰脏分泌的弹性蛋白酶在进入体循环尚未到达肺之前可被血浆蛋白酶抑制剂迅速灭活。已证明,胰弹性蛋白酶原在血清中能与α_1-抗胰蛋白酶(α_1-AT)结合,有可能使弹性蛋白酶在肺内的活化延迟。2.巨噬细胞巨噬细胞可能含有一种具有丝氨酸蛋白酶性质的弹性蛋白酶,该酶可能来自中性粒细胞,通过巨噬细胞表面受体进入细胞,但并不立即以活性形式释放。其次巨噬细胞可以产生具有金属蛋白酶性质的弹性蛋白酶(Ca~(++)-依赖)该酶不能储存,由活化的巨噬细胞释放。这种特异的巨噬细胞金属蛋白酶是否能够单独引起肺气肿,仍然未明。3.中性粒细胞人的多形核白细胞含有两种具
In recent years, it has been suggested that many of the occurrence and development of pulmonary diseases and the imbalance of protease-protease in the lung are related to the concept of chronic bronchitis and emphysema has been clear. [Sources of Elastase for Human Lung Function] 1. Elastase secreted by the pancreas of the pancreas is quickly inactivated by a plasma protease inhibitor before it enters the systemic circulation before it reaches the lungs. It has been demonstrated that pancreatic elastase can bind to α 1-antitrypsin (α 1 -AT) in serum, potentially rendering elastase active in the lungs delayed. 2. Macrophages Macrophages may contain a serine protease-like elastase, which may be derived from neutrophils and enter cells via macrophage surface receptors but are not immediately released in their active form. Second, macrophages produce elastase (Ca ~ (++) -dependent) that has the property of a metalloprotease that can not be stored and released by activated macrophages. Whether this specific macrophage metaproteinase alone can cause emphysema remains unclear. 3. Neutrophil human polymorphonuclear leukocytes contain two kinds of with