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应用多聚酶链反应技术检测了１４例急性淋巴细胞白血病（ＡＬＬ）患者的ｂｃｒ／ａｂｌ融合基因、ＴＣＲγ基因重排及ＩｇＨ基因重排，结果发现，ｂｃｒ／ａｂｌ融合基因阳性５例，阳性率３５．７％，其中４例为Ｂ－ＡＬＬ，１例ＴＣＲγ及ＩｇＨ基因重排均阴性。ｂｃｒ／ａｂｌ（＋）患者与ｂｃｒ／ａｂｌ（－）患者在临床表现方面无显著性差异，但ｂｃｒ／ａｂｌ（＋）患者治疗效果比ｂｃｒ／ａｂｌ（－）患者差。
The bcr / abl fusion gene, TCRγ gene rearrangement and IgH gene rearrangement were detected by polymerase chain reaction in 14 cases of acute lymphoblastic leukemia (ALL). The positive rate of bcr / abl fusion gene in 5 cases was 35. 7%, of which 4 cases were B-ALL, 1 case of TCRγ and IgH gene rearrangement were negative. There was no significant difference in clinical manifestations between patients with bcr / abl (+) and those with bcr / abl (-), but patients treated with bcr / abl (+) had worse outcomes than those with bcr / abl (-).