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探讨脑肿瘤的浸润转移机制 ,利用免疫组化技术对原发性脑胶质瘤间质组成进行观察。免疫组化结果显示 ,Collagen 、 Fibronection、 L aminin (Coll 、 FN、 L M)三种抗原在正常脑组织及脑瘤组织的血管基底膜和其表面被覆软脑膜均有表达 ,以 FN表达最强 ,Coll 表达稍次 ,L M表达最弱。在部分胶质瘤细胞外基质有 FN阳性表达 ,胶质瘤细胞外基质 FN阳性表达率与胶质瘤的分化程度无关。各型各级胶质瘤血管基底膜部分呈线状连续完整 ,部分呈分层网格状增厚。本研究结果提示 :活体胶质瘤细胞自身合成的 FN可能有助于瘤细胞的组织移行能力 ,在一定程度上促成了胶质瘤的浸润性生长 ;胶质瘤细胞与转移瘤细胞转移侵袭能力不同 ,为进一步探索脑瘤的转移机制 ,应重点分析瘤细胞表面大分子物质表达的特异性。
To explore the mechanism of invasion and metastasis of brain tumors, and to observe the composition of primary glioma mesenchyme using immunohistochemistry. The results of immunohistochemistry showed that Collagen, Fibronection, Laminin (Coll, FN, LM) antigens were expressed in both the normal basement and the brain tumor tissue and in the surface of the basement membrane covering the pia mater. The expression of FN was the strongest. The expression of Coll was slightly higher and LM was the weakest. In some gliomas, extracellular matrix has FN-positive expression. The positive rate of FN glioma extracellular matrix has nothing to do with the differentiation of glioma. The vascular basement membranes of various types of gliomas were linear and complete, and some were thickened in layers. The results of this study suggest that the self-synthesis of FN in living glioma cells may contribute to the ability of tumor cells to migrate, and to a certain extent, it contributes to the invasive growth of gliomas; the invasion and metastasis ability of glioma cells and metastatic cells. Differently, in order to further explore the brain tumor metastasis mechanism, the specificity of macromolecular substance expression on the surface of tumor cells should be analyzed.