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目的研究天麻钩藤饮加减方联合硝苯地平缓释片治疗高血压的临床效果。方法以2015年4月~2016年5月高血压患者90例随机分两组。西药治疗组采用硝苯地平缓释片治疗,联合治疗组采用天麻钩藤饮加减方联合硝苯地平缓释片治疗。比较两组患者高血压控制率;不良反应出现情况;治疗前和治疗后患者平均舒张压、平均收缩压、SF-36评分的差异。结果联合治疗组患者高血压控制率高于西药治疗组,P<0.05;联合治疗组不良反应出现情况和西药治疗组无显著差异,P>0.05;治疗前两组平均舒张压、平均收缩压、SF-36评分比较无显著差异,P>0.05;治疗后联合治疗组平均舒张压、平均收缩压、SF-36评分改善幅度更大,P<0.05。结论天麻钩藤饮加减方联合硝苯地平缓释片治疗高血压的临床效果确切,可有效改善患者舒张压和收缩压,提升患者生活质量,无明显副作用,用药安全性高,值得推广应用。
Objective To study the clinical effect of Tianmagouteng Decoction plus nifedipine sustained-release tablets in the treatment of hypertension. Methods From April 2015 to May 2016, 90 hypertensive patients were randomly divided into two groups. Western medicine treatment group treated with nifedipine sustained release tablets, combined treatment group with Tianma Goutou Decoction plus nifedipine sustained release tablets. The control rate of hypertension, adverse reactions, the mean diastolic blood pressure, the mean systolic blood pressure and SF-36 scores of the two groups were compared before and after treatment. Results The rate of hypertension control in the combined treatment group was higher than that in the Western medicine group (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions in the combined treatment group (P> 0.05). The mean diastolic blood pressure, SF-36 score was no significant difference, P> 0.05; after treatment, the averaged diastolic blood pressure, average systolic blood pressure and SF-36 score improved more significantly (P <0.05). Conclusion Tianma Gouteng Decoction plus nifedipine sustained-release tablets in the treatment of hypertension has an exact clinical effect, which can effectively improve diastolic and systolic blood pressure and improve the quality of life of patients with no obvious side effects and high drug safety, which is worthy of promotion and application .