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目的:观察小剂量雌激素软膏联合保妇康栓外用治疗老年阴道炎的疗效及安全性。方法:160例老年阴道炎患者随机分为观察组与对照组,各80例。对照组使用保妇康栓治疗,观察组在对照组基础上联合雌激素软膏治疗。两组均持续治疗7 d。比较两组患者治疗有效率、激素水平、临床症状消失时间、生活质量、应激状态等指标。结果:观察组治疗有效率为91.25%,明显高于对照组的80.00%(P<0.05)。治疗后,两组FSH、LH、E2水平均较治疗前明显改善(P<0.05),两组血糖水平、HAMD评分、HAMA评分、生活质量也较治疗前有明显改善(P<0.05);且观察组治疗后FSH、LH水平,以及血糖水平、HAMD评分、HAMA评分、生活质量等均优于对照组(P<0.05),两组治疗后E2比较,差异无统计学意义(P>0.05)。观察组灼热感缓解、瘙痒感缓解、阴道壁充血消退、阴道分泌物减少时间均短于对照组(P<0.01)。结论:小剂量雌激素软膏联合保妇康栓治疗老年阴道炎疗效好,利于改善患者临床症状及生活质量。
Objective: To observe the efficacy and safety of low-dose estrogen ointment combined with Baofukang suppository in the treatment of senile vaginitis. Methods: 160 elderly patients with vaginitis were randomly divided into observation group and control group, 80 cases each. The control group was treated with Baofukang suppository. The observation group was treated with estrogen ointment on the basis of the control group. Both groups continued treatment for 7 days. The treatment efficiency, hormone level, disappearance of clinical symptoms, quality of life, stress status and other indicators were compared between the two groups. Results: The effective rate of observation group was 91.25%, which was significantly higher than that of the control group (80.00%, P <0.05). After treatment, the levels of FSH, LH and E2 in both groups were significantly improved (P <0.05), and the levels of blood glucose, HAMD, HAMA and quality of life were significantly improved in both groups (P <0.05); The FSH and LH levels, blood glucose level, HAMD score, HAMA score and quality of life in the observation group were better than those in the control group (P <0.05). There was no significant difference in E2 between the two groups after treatment (P> 0.05) . The observation group was relieved of burning sensation, itching relief, vaginal wall congestion subsided, vaginal discharge reduction time were shorter than the control group (P <0.01). Conclusion: The combination of low dose estrogen ointment and Baofukang suppository has good curative effect on senile vaginitis, which will help to improve clinical symptoms and quality of life of patients.