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目的了解2009~2013年上海市虹口区含麻疹成分疫苗(measles containing vccine,MCV)预防接种不良事件(adverse event following immunization,AEFI)的发生情况及反应特征,评价MCV接种的安全性。方法通过中国免疫规划监测信息管理系统,收集上海市虹口区2009年1月1日至2013年12月31日报告的MCV AEFI个案数据,采用描述性方法进行流行病学分析。结果共报告MCV AEFI个案595例,报告发生率为371.9/10万剂次,其中一般反应532例(89.6%),第1剂次518例(87.2%),388例(65.3%)发生在接种当天。异常反应报告以过敏性皮疹为主,报告发生率为35.6/10万剂次。严重事件2例,为血小板减少性紫癜、急性脊髓炎,报告发生率均为0.6/10万剂次。MV在接种2 d及2 d以上发生的例数多于MR和MMR。不同季度采取的监测形式、不同监测形式所报告的AEFI类型无差别。结论上海市虹口区使用的MCV疫苗具有很好的安全性,但尚需对严重事件的发生提高警惕。应积极提高辖区MCV成人及免疫薄弱人群的接种率,从而有效控制近年来高发的麻疹疫情。
Objective To investigate the occurrence and response characteristics of measles containing vincine (MCV) adverse event following immunization (AEFI) in Hongkou district of Shanghai from 2009 to 2013 and evaluate the safety of MCV inoculation. Methods The data of MCV AEFI reported by Hongkou District in Shanghai from January 1, 2009 to December 31, 2013 were collected through China National Immunization Program Monitoring Information Management System. The descriptive method was used for epidemiological analysis. Results A total of 595 MCV AEFI cases were reported, with a reported incidence of 371.9 / 100 000 doses, of which 532 were general reactions (89.6%), 518 (87.2%) were in the first dose and 388 (65.3%) occurred in vaccination Same day Abnormal reaction report mainly allergic rash, the report rate was 35.6 / 100 000 doses. Serious events in 2 cases, thrombocytopenic purpura, acute myelitis, the report rate was 0.6 / 100 000 doses. MV occurred more frequently than MR and MMR on day 2 and day 2 after inoculation. There was no difference in the type of AEFI reported from the different monitoring modalities in different quarters. Conclusion The MCV vaccine used in Hongkou district of Shanghai has good safety, but vigilance should still be given to the occurrence of serious incidents. Inoculation rates of adults with MCI and immunocompromised people in the area should be actively raised so as to effectively control the outbreak of measles that has been endemic in recent years.