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目的 辛伐他汀对老年人的调脂作用和改善脑动脉血流动力学效果.方法 55例年龄60岁以上血清胆固醇>5.7mmol/L(220mg/dl)为研究组,55例年龄60岁以上血清胆固醇<5.2mmol/L(200mg/dl)者为对照组.研究组服用辛代他汀每日5mg,16周后重复血脂和脑动脉血流动力学检查.结果 研究组血清胆固醇从7.46 ±0.85降至5.73±0.90(P<0.01),甘油三脂从1.85±103降至1.70±0.88(P>0.05),低密度脂蛋白从5.97±0.86降至3.55±0.92(P<0.01).脑动脉血流动力学参数在治疗后均有改善,如血流速度平均值(左侧)由20.78±6.43增至21.97±5.29(P<0.01),脑血管外周阻力(左侧)由75.72±22.99降至64.73±20,69(P<0.01).结论 辛伐他汀治疗16周可以通过降低血管阻力增加血流量改善脑血管供血状态.
Objective To investigate the effects of simvastatin on lipid metabolism and cerebral arterial hemodynamics in elderly patients.Methods Serum cholesterol> 5.7mmol / L (220mg / dl) in 55 patients aged 60 years and over was used as the study group.Among them, 55 cases were over 60 years old Serum cholesterol <5.2mmol / L (200mg / dl) as the control group.The study group taking 5mg daily Xintiatin, repeated 16 weeks after blood lipid and cerebral arterial hemodynamics.Results The study group serum cholesterol increased from 7.46 ± 0.85 To 5.73 ± 0.90 (P <0.01), the triglyceride decreased from 1.85 ± 103 to 1.70 ± 0.88 (P> 0.05), and the low density lipoprotein decreased from 5.97 ± 0.86 to 3.55 ± 0.92 (P <0.01) Hemodynamic parameters improved after treatment, such as mean velocity of blood flow (left side) increased from 20.78 ± 6.43 to 21.97 ± 5.29 (P <0.01), and cerebral vascular resistance (left side) decreased from 75.72 ± 22.99 To 64.73 ± 20.69 (P <0.01) .Conclusion Simvastatin can improve the blood supply of cerebral blood vessels by decreasing the vascular resistance and increasing the blood flow at 16 weeks.