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目的:观察皮肤鳞状细胞癌(SCC)和基底细胞癌(BCC)组织中β-转化生长因子1(TGF-β1)及其受体1(TβR-Ⅰ)表达与临床、组织病理特征的关系。方法:应用ABC免疫组化技术检测48例皮肤SCC和41例BCC手术切除标本中TGF-β1和TβR-Ⅰ的表达。结果:SCC中TGF-β1、TβR-Ⅰ表达明显高于BCC(P<0.05);高分化SCC中TβR-Ⅰ表达明显上调(P<0.05),但TGF-β1表达与肿瘤分化程度无关(P>0.05)。SCC和BCC中TGF-β1与TβR-Ⅰ的表达呈显著正相关(r=0.739,P<0.001;r=0.716,P<0.001),但其与患者性别、年龄、病程、发病部位、病灶、淋巴结转移及BCC侵袭性无关(P>0.05)。结论:TGF-β1表达与肿瘤分化程度、侵袭性及淋巴结转移无关。
OBJECTIVE: To observe the relationship between the expression of TGF-β1 and its receptor 1 (TβR-Ⅰ) and clinical and histopathological features in human skin squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) . Methods: ABC immunohistochemistry was used to detect the expression of TGF-β1 and TβR-Ⅰ in 48 cases of skin SCC and 41 cases of BCC. Results: The expression of TGF-β1 and TβR-Ⅰ in SCC was significantly higher than that in BCC (P <0.05). The expression of TβR-Ⅰ in well differentiated SCC was significantly increased (P <0.05), but the expression of TGF- > 0.05). The expression of TGF-β1 and TβR-Ⅰ in SCC and BCC was significantly and positively correlated (r = 0.739, P <0.001; r = 0.716, P <0.001), but not with gender, age, duration of disease, Lymph node metastasis and BCC invasion (P> 0.05). Conclusion: The expression of TGF-β1 is not associated with the degree of tumor differentiation, invasion and lymph node metastasis.