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系统性红斑狼疮(SLE)病人表现有多方面的免疫异常,如淋巴细胞对有丝分裂原的反应能力降低,抑制性T细胞功能下降及E玫瑰花形成细胞减少等。还表现有血清免疫球蛋白水平升高,出现各类自身抗体等B细胞亢进现象。同时还可出现血清中循环免疫复合物(CIC)水平上升,补体水平下降。因此,SLE又是一种免疫复合物性疾病。
In patients with systemic lupus erythematosus (SLE), there are various manifestations of immune abnormalities such as diminished ability of lymphocytes to respond to mitogens, decreased function of inhibitory T cells, and decreased formation of E-rosette cells. Also showed increased serum immunoglobulin levels, there are all kinds of autoantibodies and other B-cell hyperthyroidism phenomenon. At the same time, serum levels of circulating immune complexes (CICs) may also rise and complement levels may decrease. Therefore, SLE is an immune complex disease.