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目的观察复方嗜酸乳杆菌联合小麦纤维素治疗肝性脑病的临床疗效。方法将48例肝性脑病患者随机分成A、B两组,A组24例在常规综合治疗的基础上给予复方嗜酸乳杆菌联合小麦纤维素治疗,B组24例在常规综合治疗的基础上仅给予小麦纤维素治疗,观察两组数字连接试验,数字符号试验,血氨及肝功能的变化,数据采用统计学方法分析。结果与B组比较,A组数字连接实验(NCT)的缩短、数字符号试验(DST)评分的增加及血氨含量下降明显,差异有统计学意义(P<0.01),A组肝功能改善亦明显(P<0.05)。结论在常规综合治疗的前提下,复方嗜酸乳杆菌联合小麦纤维素治疗肝性脑病的疗效优于单用小麦纤维素,有利于患者症状的缓解、血氨的下降及肝功能的保护。
Objective To observe the clinical efficacy of Lactobacillus acidophilus combined with wheat cellulose in the treatment of hepatic encephalopathy. Methods Forty-eight patients with hepatic encephalopathy were randomly divided into A and B groups. 24 cases in group A were given Lactobacillus acidophilus combined with wheat cellulose on the basis of conventional comprehensive treatment, and 24 cases in group B were treated with conventional combined therapy The treatment of wheat cellulose was given only. The changes of digital ammunition test, digital sign test, blood ammonia and liver function were observed. The data were analyzed by statistical methods. Results Compared with group B, the shortening of digital connection test (NCT), the increase of digital sign test (DST) and the decrease of serum ammonia in group A were significantly (P <0.01), and the improvement of liver function in group A Obviously (P <0.05). Conclusions Under the premise of conventional comprehensive treatment, the efficacy of Lactobacillus acidophilus combined with wheat cellulose in treating hepatic encephalopathy is better than that of single wheat cellulose, which is good for the relief of symptoms, the decrease of blood ammonia and the protection of liver function.