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成人型多囊肾病(adult polgcystic kidney disease,简称APKD)是一种常染色体显性遗传病.1985年英国学者Reeders等报道APKD基因与位于16号染色体短臂上的α珠蛋白基因3’HVRC(3’hy-pervariable region)之间具有紧密连锁关系,其重组率为5％,并成功地应用于产前诊断.
Adult polgcystic kidney disease (APKD) is an autosomal dominant disease.In 1985 British scholar Reeders et al reported that the APKD gene is located on the short arm of chromosome 16 with the alpha-globin gene 3’HVRC ( 3’hy-pervariable region). The recombination rate was 5% and was successfully applied to prenatal diagnosis.