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用双盲法给6名健康受试者口服丙氟哌酸(CF)250mg 和500mg,给药前夜禁食,给药前及给药后0.5、1、1.5、2、3、4、6、8、12和24h 采血;并留取0～2、2～4、4～8、8～12、12～24h 尿样,用琼脂打孔扩散法测血、尿药浓度。指示菌为肺炎杆菌ATCC 10031,数据由一室模型非线性最小两乘法分析得到。结果显示,给药250mg,血药浓度在1h 达高峰,为1.45±0.58μg/ml,8h和12h 血浓度为0.25 ug/ml 和0.12μg/ml;而500mg达峰时间为1.33h,峰浓度2.46±0.94μg/ml,8、12h血浓度分别为0.44和0.22 ug/ml;250mg 和500mg
Six healthy subjects were orally administered with 250 mg and 500 mg of propoxypic acid (CF) by double-blind method. The rats were fasted on the night before administration and were administered 0.5, 1, 1.5, 2, 3, Blood samples were taken at 8, 12, and 24 hours. Urine samples were collected for 0, 2, 4, 4, 8, 12, 12, and 24 hours. The indicator bacteria were Klebsiella pneumonia ATCC 10031, and the data were obtained by non-linear least squares multiplication analysis of one-compartment model. The results showed that the administration of 250mg, plasma concentration peaked at 1h, 1.45 ± 0.58μg / ml, 8h and 12h blood concentrations of 0.25 ug / ml and 0.12μg / ml; and 500mg peak time was 1.33h, the peak concentration 2.46 ± 0.94μg / ml, 8,12h blood concentrations were 0.44 and 0.22 ug / ml; 250mg and 500mg