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目的探讨10例侧脑室注射STZ术后出现肠梗阻大鼠的治疗方案,提高该术后大鼠的存活率。方法予60只大鼠侧脑室注射STZ观察1周后,选取其中出现不同程度肠梗阻大鼠10例用开塞露灌肠,大黄水灌胃并间断给予软食的方法治疗。结果治愈2例,无效死亡8例,死亡大鼠尸检结果为中位梗阻伴见肠胀气,偶见穿孔、坏死等。结论该治疗方案简单有效,有利于提高侧脑室注射STZ术后存活率,但使用时也有一些注意事项。
Objective To investigate the treatment of intestinal obstruction in 10 rats after intracerebroventricular injection of STZ and to improve the survival rate of the rats. Methods Sixty rats were injected intracerebroventricular (icv) injection of STZ for 1 week. Ten rats with different degrees of intestinal obstruction were selected for treatment with Kaiserluo enema, rhubarb water and intermittent soft diet. Results of 2 cases were cured, 8 cases of ineffective death, necrosis of the autopsy results for the median obstruction with flatulence, occasionally perforation, necrosis. Conclusion The treatment regimen is simple and effective, which is beneficial to improve the survival rate after intracerebroventricular injection of STZ, but there are some precautions when used.